Journal
BIOSENSORS & BIOELECTRONICS
Volume 25, Issue 3, Pages 553-557Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2009.06.042
Keywords
Chemometrics; Molecularly imprinted polymer; Molecular imprinting; Bupivacaine; Principal component analysis; Dielectric constant; Snyder polarity index; Radioligand binding
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Funding
- Swedish Research Council (VR)
- Knowledge Foundation (KKS)
- University of Kalmar
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The influence of the physical properties of incubation medium on the rebinding of template to bupivacaine molecularly imprinted and non-imprinted methacrylic acid-ethylene dimethacrylate co-polymers has been studied. Principal component analysis (PCA) was employed to identify the factors with the greatest influence on binding. While the dielectric constant (D) made a significant contribution to describing the observed binding, the influence of polarity as reflected in the Snyder polarity index (SPI) was also demonstrated to make a significant contribution. The use of solvents containing hydroxyl functionality in particular was observed to exert unique effects on recognition. The variation in solvent influence on binding at constant D motivates more complex analyses when studying MIP-ligand recognition. (C) 2009 Elsevier B.V. All rights reserved.
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