Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume 58, Issue 8, Pages 1294-1309Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2016.1252712
Keywords
Gut; microbiota; type 2 diabetes; obesity; environment; lifestyle; GLP-1; serotonin; Roux-y-gastric-by-pass; GIP
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Funding
- NNF Center for Basic Metabolic Research [Holst Group] Funding Source: researchfish
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The gut regulates glucose and energy homeostasis; thus, the presence of ingested nutrients into the gut activates sensing mechanisms that affect both glucose homeostasis and regulate food intake. Increasing evidence suggest that gut may also play a key role in the pathogenesis of type 2 diabetes which may be related to both the intestinal microbiological profile and patterns of gut hormones secretion. Intestinal microbiota includes trillions of microorganisms but its composition and function may be adversely affected in type 2 diabetes. The intestinal microbiota may be responsible of the secretion of molecules that may impair insulin secretion/action. At the same time, intestinal milieu regulates the secretion of hormones such as GLP-1, GIP, ghrelin, gastrin, somatostatin, CCK, serotonin, peptide YY, GLP-2, all of which importantly influence metabolism in general and in particular glucose metabolism. Thus, the aim of this paper is to review the current evidence on the role of the gut in the pathogenesis of type 2 diabetes, taking into account both hormonal and microbiological aspects.
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