Journal
BIOSENSORS & BIOELECTRONICS
Volume 24, Issue 1, Pages 55-59Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2008.03.022
Keywords
electrophoretic deposition; layer-by-layer deposition; glucose sensing; gold nanoparticles; redox polymer; glucose oxidase; microelectrodes
Categories
Funding
- Commission of the European Communities [IST-2002-1-001837]
- HEALTHY AIMS [QLRT-2001-01678]
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The design of an electrochemical glucose sensing device formed by the electrodeposition of multifunctional Au nanciparticles is reported here as a novel concept for an enhanced generic sensing platform, Initially gold nanoparticles (Au) were alternatively coated with a layer of positively charged redox polymer (ORP) and a negatively charged glucose oxidase (GOX) layer alternatively using layer-by-layer methodology to form multifunctional Au/ORP/GOX/ORP particles. The modification and stability of the Au nanoparticles was monitored by using UV-vis spectroscopy and zeta-potential measurements. The modified Au nanciparticles were electrophoretically deposited onto an electrode to produce an electrochemical glucose sensing device. A considerable influence of electrophoretic deposition time and potential was found on the sensing platform response. Preliminary responses to glucose addition showed an enhanced performance by applying an electrophoretic deposition potential of +1.2 V vs. Ag/AgCl for 30 min. The observed response in the case of microelectrode geometry was in the range of mA cm(2). This work also shows that the presence of a second outer ORP layer on the functionalised Au nanoparticles improved the response. (C) 2008 Elsevier B.V. All rights reserved.
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