Journal
CELL CHEMICAL BIOLOGY
Volume 25, Issue 10, Pages 1279-+Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2018.05.018
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Funding
- Radboud University Medical Center [KUN2015-7604]
- NWO Netherlands Research School for Chemical Biology (NRSCB)
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Pathogens such as non-typeable Haemophilus influenzae (NTHi) evade the immune system by presenting host-derived sialic acids. NTHi cannot synthesize sialic acids and therefore needs to utilize sialic acids originating from host tissue. Here we report sialic acid-based probes to visualize and inhibit the transfer of host sialic acids to NTHi. Inhibition of sialic acid utilization by NTHi enhanced serum-mediated killing. Furthermore, in an in vitro model of the human respiratory tract, we demonstrate efficient inhibition of sialic acid transfer from primary human bronchial epithelial cells to NTHi using bioorthogonal chemistry.
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