Journal
BIOSCIENCE REPORTS
Volume 33, Issue -, Pages 187-197Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BSR20120059
Keywords
chromosome; enzyme; GAPDH; histone 2B; S-phase
Categories
Funding
- Agency for Science, Technology and Research, Singapore
- Zhejiang University College of Medicine
- Fundamental Research Funds for the Central Universities
- NATIONAL CANCER INSTITUTE [P30CA006973] Funding Source: NIH RePORTER
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The concept of one-protein-multiple-function, i.e. moonlighting proteins, is an ever-expanding paradigm. We obtained compelling evidence that an array of 'cytoplasmic' metabolic enzymes can enter the nuclei to carry out moonlighting transcription functions; this phenomenon is conserved from Drosophila to humans. Of particular interest are the classical glycolytic enzymes GAPDH (glyceraldehyde-3-phosphate dehydrogenase) and LDH (lactate dehydrogenase), which utilize NAD(H) as coenzymes and not only moonlight (in their nuclear forms) to regulate the transcription of S-phase-specific histone genes, but also act as metabolic/redox sensors that link histone gene switching to DNA replication and S-phase progression.
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