Related references
Note: Only part of the references are listed.The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui et al.
JOURNAL OF IMMUNOLOGY (2015)
Mechanisms of Leukocyte Transendothelial Migration
William A. Muller
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6 (2011)
The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes
Rachel Evans et al.
BLOOD (2011)
A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis
Matthew MacPherson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Structures and Interaction Analyses of Integrin αMβ2 Cytoplasmic Tails
Geok-Lin Chua et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins
Hong Qu et al.
JOURNAL OF CELL SCIENCE (2011)
Cathepsin X cleavage of the β2 integrin regulates talin-binding and LFA-1 affinity in T cells
Zala Jevnikar et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2011)
Leukocyte integrin αLβ2 transmembrane association dynamics revealed by coarse-grained molecular dynamics simulations
Choon-Peng Chng et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2011)
Regulating neutrophil apoptosis: new players enter the game
Veronique Witko-Sarsat et al.
TRENDS IN IMMUNOLOGY (2011)
Molecular Architecture and Function of Matrix Adhesions
Benjamin Geiger et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)
Molecular Dynamics Simulations of Forced Unbending of Integrin αVβ3
Wei Chen et al.
PLOS COMPUTATIONAL BIOLOGY (2011)
CD11c Expression in Adipose Tissue and Blood and Its Role in Diet-Induced Obesity
Huaizhu Wu et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)
Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners
Yukihiko Ebisuno et al.
BLOOD (2010)
Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils
Yoshihiro Kuwano et al.
BLOOD (2010)
E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin αLβ2-mediated slow leukocyte rolling
Tadayuki Yago et al.
BLOOD (2010)
RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo
David Frommhold et al.
BLOOD (2010)
Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro
Alison McDowall et al.
BLOOD (2010)
Human polymorphonuclear leucocytes stimulated by tumour necrosis factor-alpha show increased adherence to extracellular matrix proteins which is mediated via the CD11b/18 complex
H. L. THOMPSON et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2010)
Structure of an integrin with an αI domain, complement receptor type 4
Can Xie et al.
EMBO JOURNAL (2010)
T Cell Receptor Inside-Out Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes
Monika Raab et al.
IMMUNITY (2010)
The Integrin Co-activator Kindlin-3 Is Expressed and Functional in a Non-hematopoietic Cell, the Endothelial Cell
Katarzyna Bialkowska et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds
Wei Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Recreation of the terminal events in physiological integrin activation
Feng Ye et al.
JOURNAL OF CELL BIOLOGY (2010)
The switchable integrin adhesome
Ronen Zaidel-Bar et al.
JOURNAL OF CELL SCIENCE (2010)
Rap1 Controls Activation of the αMβ2 Integrin in a Talin-Dependent Manner
Jenson Lim et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2010)
Integrin alpha(M)beta(2) Clustering Triggers Phosphorylation and Activation of Protein Kinase C delta that Regulates Transcription Factor Foxp1 Expression in Monocytes
Zhi-Hong Xue et al.
JOURNAL OF IMMUNOLOGY (2010)
A Transmembrane Polar Interaction Is Involved in the Functional Regulation of Integrin αLβ2
Ardcharaporn Vararattanavech et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b
Chaofeng Han et al.
NATURE IMMUNOLOGY (2010)
The final steps of integrin activation: the end game
Sanford J. Shattil et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
The FERM domain: organizing the structure and function of FAK
Margaret C. Frame et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
Paul R. Elliott et al.
STRUCTURE (2010)
Understanding the Structure and Function of the Immunological Synapse
Michael L. Dustin et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
The Ins and Outs of Leukocyte Integrin Signaling
Clare L. Abram et al.
ANNUAL REVIEW OF IMMUNOLOGY (2009)
Regulation of integrin activity and signalling
Carl G. Gahmberg et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)
LAD-1/variant syndrome is caused by mutations in FERMT3
Taco W. Kuijpers et al.
BLOOD (2009)
Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells
Thomas Quast et al.
BLOOD (2009)
Genetic etiologies of leukocyte adhesion defects
Amos Etzioni
CURRENT OPINION IN IMMUNOLOGY (2009)
The structure of the integrin αIIbβ3 transmembrane complex explains integrin transmembrane signalling
Tong-Lay Lau et al.
EMBO JOURNAL (2009)
Cathepsin X cleaves the β2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and α-actinin-1 binding
Zala Jevnikar et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2009)
The β2 Integrin CD11b Attenuates Polyinosinic:Polycytidylic Acid-Induced Hepatitis by Negatively Regulating Natural Killer Cell Functions
Minggang Zhang et al.
HEPATOLOGY (2009)
Organization of proximal signal initiation at the TCR:CD3 complex
Clifford S. Guy et al.
IMMUNOLOGICAL REVIEWS (2009)
Disruption of the Integrin αLβ2 Transmembrane Domain Interface by β2 Thr-686 Mutation Activates αLβ2 and Promotes Micro-clustering of the αL Subunits
Ardcharaporn Vararattanavech et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
NMR Solution Conformations and Interactions of Integrin αLβ2 Cytoplasmic Tails
Anirban Bhunia et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Migfilin, a Molecular Switch in Regulation of Integrin Activation
Sujay Subbayya Ithychanda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation
Nicholas J. Anthis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Kindlin-1 and-2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects
David S. Harburger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The Structure of an Interdomain Complex That Regulates Talin Activity
Benjamin T. Goult et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control β3-integrin clustering
Frederic Saltel et al.
JOURNAL OF CELL BIOLOGY (2009)
Demonstration of catch bonds between an integrin and its ligand
Fang Kong et al.
JOURNAL OF CELL BIOLOGY (2009)
The mechanical integrin cycle
Eileen Puklin-Faucher et al.
JOURNAL OF CELL SCIENCE (2009)
Integrins and cell-fate determination
Charles H. Streuli
JOURNAL OF CELL SCIENCE (2009)
Src Homology 2-Domain Containing Leukocyte-Specific Phosphoprotein of 76 kDa Is Mandatory for TCR-Mediated Inside-Out Signaling, but Dispensable for CXCR4-Mediated LFA-1 Activation, Adhesion, and Migration of T Cells
Jessica Horn et al.
JOURNAL OF IMMUNOLOGY (2009)
Osteopontin Enhances Phagocytosis through a Novel Osteopontin Receptor, the αxβ2 Integrin
Lotte Schack et al.
JOURNAL OF IMMUNOLOGY (2009)
The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation
Benjamin T. Goult et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3
Jieqing Zhu et al.
MOLECULAR CELL (2009)
Kindlin-3 is required for β2 integrin-mediated leukocyte adhesion to endothelial cells
Markus Moser et al.
NATURE MEDICINE (2009)
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
Nikolay L. Malinin et al.
NATURE MEDICINE (2009)
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation
Lena Svensson et al.
NATURE MEDICINE (2009)
The Tail of Integrins, Talin, and Kindlins
Markus Moser et al.
SCIENCE (2009)
The Kindlin protein family: new members to the club of focal adhesion proteins
Alexander Meves et al.
TRENDS IN CELL BIOLOGY (2009)
The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development
Deborah K. Morrison
TRENDS IN CELL BIOLOGY (2009)
Permissive transmembrane helix heterodimerization is required for the expression of a functional integrin
Ardcharaporn Vararattanavech et al.
BIOCHEMICAL JOURNAL (2008)
Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function
Can Shi et al.
BLOOD (2008)
beta 2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding
Heikki Takala et al.
BLOOD (2008)
alpha-actinin structure and regulation
B. Sjoeblom et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Urokinase-type plasminogen activator receptor induces conformational changes in the integrin αMβ2 headpiece and reorientation of its transmembrane domains
Man-Li Tang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Kindlin-2 (Mig-2):: a co-activator of β3 integrins
Yan-Qing Ma et al.
JOURNAL OF CELL BIOLOGY (2008)
Talin at a glance
David R. Critchley et al.
JOURNAL OF CELL SCIENCE (2008)
PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling
Alexander Zarbock et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Neutrophil apoptosis:: Selective regulation by different ligands of integrin αMβ2
Elzbieta Pluskota et al.
JOURNAL OF IMMUNOLOGY (2008)
Structural insight into the function of myelin basic protein as a ligand for integrin αMβ2
Romualdas Stapulionis et al.
JOURNAL OF IMMUNOLOGY (2008)
Intercellular adhesion molecule-3 binding of integrin αLβ2 requires both extension and opening of the integrin headpiece
Xiao-Yan Tang et al.
JOURNAL OF IMMUNOLOGY (2008)
Transmigration of Neutrophils across Inflamed Endothelium Is Signaled through LFA-1 and Src Family Kinase
Melissa R. Sarantos et al.
JOURNAL OF IMMUNOLOGY (2008)
RACK1 regulates directional cell migration by acting on Gβγ at the interface with its effectors PLCβ and PI3Kγ
Songhai Chen et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
An unusual allosteric mobility of the C-terminal helix of a high-affinity αL integrin I domain variant bound to ICAM-5
Hongmin Zhang et al.
MOLECULAR CELL (2008)
Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces
Jianghai Zhu et al.
MOLECULAR CELL (2008)
A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus
Swapan K. Nath et al.
NATURE GENETICS (2008)
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
John B. Harley et al.
NATURE GENETICS (2008)
Kindlin-3 is essential for integrin activation and platelet aggregation
Markus Moser et al.
NATURE MEDICINE (2008)
An integrin phosphorylation switch -: The effect of β3 integrin tail phosphorylation on Dok1 and talin binding
Camilla L. Oxley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Intermediate-affinity LFA-1 binds α-actinin-1 to control migration at the leading edge of the T cell
Paula Stanley et al.
EMBO JOURNAL (2008)
Essential role for Rap1 GTPase and its guanine exchange factor CaIDAG-GEFI in LFA-1 but not VLA-4 integrin-mediated human T-cell adhesion
Haifa Ghandour et al.
BLOOD (2007)
Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration
Mandy Miertzschke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Binding between the Integrin αXβ2 (CD11c/CD18) and heparin
Thomas Vorup-Jensen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
A structural hypothesis for the transition between bent and extended conformations of the leukocyte β2 integrins
MinLong Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forcesm
Eilon Woolf et al.
NATURE IMMUNOLOGY (2007)
Structure and mechanics of integrin-based cell adhesion
M. Amin Arnaout et al.
CURRENT OPINION IN CELL BIOLOGY (2007)
Immunoreceptor-like signaling by β2 and β3 integrins
Zoltan Jakus et al.
TRENDS IN CELL BIOLOGY (2007)
Differential regulation of CD11b on γδ T cells and monocytes in response to unripe apple polyphenols
Jill C. Graff et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2007)
The cytosolic protein Talin induces an intermediate affinity integrin αLβ2
Yan-Feng Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Functional atlas of the integrin adhesome
Ronen Zaidel-Bar et al.
NATURE CELL BIOLOGY (2007)
The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility
Xiaohua Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation
Driss Ehirchiou et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
Gael Menasche et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Transcellular diapedesis is initiated by invasive podosomes
Christopher V. Carman et al.
IMMUNITY (2007)
p150/95 (CD11c/CD18) expression is required for the development of experimental autoimmune encephalomyelitis
Daniel C. Bullard et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Cytoskeletal protein radixin activates integrin αMβ2 by binding to its cytoplasmic tail
Pingtao Tang et al.
FEBS LETTERS (2007)
Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation
Georg Varga et al.
BLOOD (2007)
Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4
Eveliina Ihanus et al.
BLOOD (2007)
Phosphorylation of the LFA-1 integrin β2-chain on Thr-758 leads to adhesion, Rac-1/Cdc42 activation, and stimulation of CD69 expression in human T cells
Susanna M. Nurmi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Structural basis of integrin activation by talin
Kate L. Wegener et al.
CELL (2007)
Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells
Ronen Alon et al.
IMMUNITY (2007)
Spleen tyrosine kinase syk is necessary for E-Selectin-induced alpha(L)beta 2 integrin-mediated rolling on intercellular adhesion molecule-1
Alexander Zarbock et al.
IMMUNITY (2007)
Importance of force linkage in mechanochemistry of adhesion receptors
Nathan S. Astrof et al.
BIOCHEMISTRY (2006)
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
Attila Mocsai et al.
NATURE IMMUNOLOGY (2006)
Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade
Mia Phillipson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
α-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation
Susanna C. Fagerholm et al.
BLOOD (2006)
How the headpiece hinge angle is opened: new insights into the dynamics of integrin activation
Eileen Puklin-Faucher et al.
JOURNAL OF CELL BIOLOGY (2006)
Activation of leukocyte β2 integrins by conversion from bent to extended conformations
Noritaka Nishida et al.
IMMUNITY (2006)
Down-regulation of integrin αMβ2 ligand-binding function by the urokinase-type plasminogen activator receptor
Man-Li Tang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Reconstructing and deconstructing agonist-induced activation of integrin αIIbβ3
Jaewon Han et al.
CURRENT BIOLOGY (2006)
Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion
Koko Katagiri et al.
NATURE IMMUNOLOGY (2006)
Selective recruitment of src family kinase Hck by leukocyte integrin αMβ2 but not αLβ2 or αXβ2
Ren-Hong Tang et al.
FEBS LETTERS (2006)
The apoptotic-cell receptor CR3, but not ανβ5, is a regulator of human dendritic-cell immunostimulatory function
Mojca Skoberne et al.
BLOOD (2006)
The Rap GTPases mediate CXCL13- and sphingosine 1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes
Caylib A. Durand et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2006)
Filamins: promiscuous organizers of the cytoskeleton
Grzegorz M. Popowicz et al.
TRENDS IN BIOCHEMICAL SCIENCES (2006)
The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating β2 integrin affinity and valency in neutrophils, but are required for β2 integrin-mediated outside-in signaling involved in sustained adhesion
Cinzia Giagulli et al.
JOURNAL OF IMMUNOLOGY (2006)
The muscle protein Dok-7 is essential for neuromuscular synaptogenesis
Kumiko Okada et al.
SCIENCE (2006)
Src-family kinases mediate an outside-in signal necessary for β2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin
Licia Totani et al.
BIOCHEMICAL JOURNAL (2006)
Two distinct cytoplasmic regions of the β2 integrin chain regulate RhoA function during phagocytosis
AS Wiedemann et al.
JOURNAL OF CELL BIOLOGY (2006)
Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcγR- and complement-mediated phagocytosis
AB Hall et al.
IMMUNITY (2006)
The molecular basis of filamin binding to integrins and competition with talin
T Kiema et al.
MOLECULAR CELL (2006)
Gene duplication and functional divergence during evolution of the cytoskeletal linker protein talin
MA Senetar et al.
GENE (2005)
The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function
WC Horne et al.
IMMUNOLOGICAL REVIEWS (2005)
Specific integrin α and β chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms
SC Fagerholm et al.
JOURNAL OF CELL BIOLOGY (2005)
Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitis
DC Bullard et al.
JOURNAL OF IMMUNOLOGY (2005)
Differential activation of LFA-1 and Mac-1 ligand binding domains
SE Walters et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
CXCL13 is an arrest chemokine for B cells in high endothelial venules
N Kanemitsu et al.
BLOOD (2005)
The crystal structure of the plexin-semaphorin-integrin domain/hybrid domain/I-EGF1 segment from the human integrin β2 subunit at 1.8-Å resolution
ML Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Epitope mapping of monoclonal antibody to integrin αLβ2 hybrid domain suggests different requirements of affinity states for intercellular adhesion molecules (ICAM)-1 and ICAM-3 binding
RH Tang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-α-activated vascular endothelium under flow
L Yang et al.
BLOOD (2005)
A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes
A Smith et al.
JOURNAL OF CELL BIOLOGY (2005)
Neutrophil β2 integrins:: moderators of life or death decisions
TN Mayadas et al.
TRENDS IN IMMUNOLOGY (2005)
Integrin CD11a cytoplasmic tail interacts with the CD45 membrane-proximal protein tyrosine phosphatase domain 1
X Geng et al.
IMMUNOLOGY (2005)
Importance of integrin LFA-1 deactivation for the generation of immune responses
M Semmrich et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines
R Shamri et al.
NATURE IMMUNOLOGY (2005)
Three-dimensional EM structure of the ectodomain of integrin αVβ3 in a complex with fibronectin
BD Adair et al.
JOURNAL OF CELL BIOLOGY (2005)
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering
BH Luo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin αLβ2
G Song et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
LDL-receptor-related protein regulates beta 2-integrin-mediated leukocyte adhesion
PPEM Spijkers et al.
BLOOD (2005)
Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin αxβ2
T Vorup-Jensen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function
HL Ostergaard et al.
IMMUNOLOGIC RESEARCH (2005)
Regulation of outside-in signaling in platelets by integrin-associated protein kinase Cβ
CS Buensuceso et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Structural basis for vertebrate filamin dimerization
R Pudas et al.
STRUCTURE (2005)
Integrin αMβ2 orchestrates and accelerates plasminogen activation and fibrinolysis by neutrophils
E Pluskota et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Locomotion of monocytes on endothelium is a critical step during extravasation
AR Schenkel et al.
NATURE IMMUNOLOGY (2004)
Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-γ1
K Katagiri et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring
W Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
An endothelial laminin isoform, laminin 8 (α4β1γ1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis
Z Wondimu et al.
BLOOD (2004)
LFA-1 contributes an early signal for NK cell cytotoxicity
DF Barber et al.
JOURNAL OF IMMUNOLOGY (2004)
P marks the spot: site-specific integrin phosphorylation regulates molecular interactions
SC Fagerholm et al.
TRENDS IN BIOCHEMICAL SCIENCES (2004)
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization
J Jin et al.
CURRENT BIOLOGY (2004)
Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1
C Shi et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
Characterization of plasminogen as an adhesive ligand for integrins αMβ2 (Mac-1) and α5β1 (VLA-75)
VK Lishko et al.
BLOOD (2004)
The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin α4β7
JF Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The integrin αLβ2 hybrid domain serves as a link for the propagation of activation signal from its stalk regions to the I-like domain
E Tng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes
HZ Wu et al.
JOURNAL OF IMMUNOLOGY (2004)
Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility
AP Wheeler et al.
EXPERIMENTAL CELL RESEARCH (2004)
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
T Xiao et al.
NATURE (2004)
The integrin α-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation
C Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them
CV Carman et al.
JOURNAL OF CELL BIOLOGY (2004)
Role of ADMIDAS cation-binding site in ligand recognition by integrin α5β1
AP Mould et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
FRET detection of cellular α4-integrin conformational activation
A Chigaev et al.
BIOPHYSICAL JOURNAL (2003)
Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster
JF Chen et al.
NATURE STRUCTURAL BIOLOGY (2003)
The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: A novel pathway for inflammatory cell recruitment
T Chavakis et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Src kinase activation by direct interaction with the integrin β cytoplasmic domain
EG Arias-Salgado et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Integrin avidity regulation: are changes in affinity and conformation underemphasized?
CV Carman et al.
CURRENT OPINION IN CELL BIOLOGY (2003)
Activation of Rac2 and Cdc42 on Fc and complement receptor ligation in human neutrophils
M Forsberg et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2003)
Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins
M Kim et al.
SCIENCE (2003)
Vav1 phosphorylation is induced by β2 integrin engagement on natural killer cells upstream of actin cytoskeleton and lipid raft reorganization
B Riteau et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment
A Smith et al.
JOURNAL OF CELL SCIENCE (2003)
RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1
K Katagiri et al.
NATURE IMMUNOLOGY (2003)
The critical cytoplasmic regions, of the αL/β2 integrin in Rap1-induced adhesion and migration
Y Tohyama et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Conformational changes in the integrin βA domain provide a mechanism for signal transduction via hybrid domain movement
AP Mould et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement
E Caveggion et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2003)
Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow
M Shimonaka et al.
JOURNAL OF CELL BIOLOGY (2003)
Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation
YZ Tu et al.
CELL (2003)
Characterization of ICAM-4 binding to the I domains of the CD11a/CD18 and CD11b/CD18 leukocyte integrins
E Ihanus et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2003)
Integrin β cytoplasmic domain interactions with phosphotyrosine-binding domains:: A structural prototype for diversity in integrin signaling
DA Calderwood et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Structure and allosteric regulation of the αXβ2 integrin I domain
T Vorup-Jensen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Convergence of the adhesive and fibrinolytic systems:: recognition of urokinase by integrin αMβ2 as well as by the urokinase receptor regulates cell adhesion and migration
E Pluskota et al.
BLOOD (2003)
Regulation of CD11b/CD18 (Mac-1) adhesion to fibrinogen by urokinase receptor (uPAR)
H Zhang et al.
INFLAMMATION RESEARCH (2003)
Structures of the αL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation
M Shimaoka et al.
CELL (2003)
Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1
OD Perez et al.
NATURE IMMUNOLOGY (2003)
Structural determinants of integrin recognition by Talin
B Garcia-Alvarez et al.
MOLECULAR CELL (2003)
Stabilizing the integrin αM inserted domain in alternative conformations with a range of engineered disulfide bonds
M Shimaoka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
The RACK1 scaffold protein: A dynamic cog in cell response mechanisms
A McCahill et al.
MOLECULAR PHARMACOLOGY (2002)
The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin β cytoplasmic domains
DG Woodside et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Integrins: Bidirectional, allosteric signaling machines
RO Hynes
CELL (2002)
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling
J Takagi et al.
CELL (2002)
A structural mechanism of integrin αIIbβ3 inside-out activation as regulated by its cytoplasmic face
O Vinogradova et al.
CELL (2002)
The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1
S Santoso et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectively
V Le Cabec et al.
JOURNAL OF IMMUNOLOGY (2002)
Integrin activation and structural rearrangement
J Takagi et al.
IMMUNOLOGICAL REVIEWS (2002)
The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (CXCL12): Potential role for Rap2 in promoting B cell migration
SJ McLeod et al.
JOURNAL OF IMMUNOLOGY (2002)
Identification of integrin αMβ2 as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2):: immediate-early gene products expressed in atherosclerotic lesions
JM Schober et al.
BLOOD (2002)
Crystal structure of the extracellular segment of integrin αVβ3 in complex with an Arg-Gly-Asp ligand
JP Xiong et al.
SCIENCE (2002)
Imaging synapse formation during thymocyte selection:: Inability of CD3ζ to form a stable central accumulation during negative selection
LI Richie et al.
IMMUNITY (2002)
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation
N Beglova et al.
NATURE STRUCTURAL BIOLOGY (2002)
Syk is required for integrin signaling in neutrophils
A Mócsai et al.
IMMUNITY (2002)
JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes
G Ostermann et al.
NATURE IMMUNOLOGY (2002)
Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes
S Fagerholm et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling
E Sebzda et al.
NATURE IMMUNOLOGY (2002)
Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration
DA Calderwood et al.
NATURE CELL BIOLOGY (2001)
Superantigen-induced T Cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70
MM Morgan et al.
JOURNAL OF IMMUNOLOGY (2001)
Leukocyte integrin Mac-1 recruits toll/interleukin-1 receptor superfamily signaling intermediates to modulate NF-κB activity
C Shi et al.
CIRCULATION RESEARCH (2001)
Crystal structure of the extracellular segment of integrin αVβ3
JP Xiong et al.
SCIENCE (2001)
The N-terminal region and the mid-region complex of the integrin β2 subunit
SM Tan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Analysis of the mammalian talin2 gene TLN2
SJ Monkley et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation
J Grimm et al.
JOURNAL OF CELL BIOLOGY (2001)
RhoA is required for monocyte tail retraction during transendothelial migration
RA Worthylake et al.
JOURNAL OF CELL BIOLOGY (2001)
Identification of a phospholipase C-γ1 (PLC-γ1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-γ1 and NFAT
D Yablonski et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Activation of RhoA and ROCK are essential for detachment of migrating Leukocytes
J Alblas et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines
G Cinamon et al.
NATURE IMMUNOLOGY (2001)
Reversibly locking a protein fold in an active conformation with a disulfide bond:: Integrin αL I domains with high affinity and antagonist activity in vivo
M Shimaoka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
C-terminal opening mimics 'inside-out' activation of integrin α5β1
J Takagi et al.
NATURE STRUCTURAL BIOLOGY (2001)
Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin β2 subunit that restrain activation of the integrin αxβ2
Q Zang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Filamins as integrators of cell mechanics and signalling
TP Stossel et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)
Differential roles for αMβ2 integrin clustering or activation in the control of apoptosis via regulation of Akt and ERK survival mechanisms
BB Whitlock et al.
JOURNAL OF CELL BIOLOGY (2000)
An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain
JP Xiong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Chemokines trigger immediate β2 integrin affinity and mobility changes:: Differential regulation and roles in lymphocyte arrest under flow
G Constantin et al.
IMMUNITY (2000)
Ligand binding to integrins
EF Plow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Genetic analysis of integrin function in man: LAD-1 and other syndromes
N Hogg et al.
MATRIX BIOLOGY (2000)
Human blood monocytes interact with type I collagen through αxß2 integrin (CD11c-CD18, gp150-95)
R Garnotel et al.
JOURNAL OF IMMUNOLOGY (2000)
Cytohesin-1 regulates β-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1
C Geiger et al.
EMBO JOURNAL (2000)
Identification of a urokinase receptor-integrin interaction site - Promiscuous regulator of integrin function
DI Simon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
CR3: a general purpose adhesion-recognition receptor essential for innate immunity
MRW Ehlers
MICROBES AND INFECTION (2000)
Regulatory and signaling properties of the Vav family
XR Bustelo
MOLECULAR AND CELLULAR BIOLOGY (2000)
A structural basis for integrin activation by the cytoplasmic tail of the αIIb-subunit
O Vinogradova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Structural basis of collagen recognition by integrin α2β1
J Emsley et al.
CELL (2000)
Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase
K Katagiri et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Share Paper
