Journal
BIOSCIENCE REPORTS
Volume 31, Issue 5, Pages 303-307Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BSR20100134
Keywords
cell adhesion; colon cancer; protein tyrosine phosphatase receptor-T (PTPRT); receptor protein tyrosine phosphatases type IIB; tumour suppressor
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Funding
- National Institutes of Health [R01-CA127590]
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It has long been thought that PTPs (protein tyrosine phosphatases) normally function as tumour suppressors. Recent high-throughput mutational analysis identified loss-of-function mutations in six PTPs in human colon cancers, providing critical cancer genetics evidence that PTPs can act as tumour suppressor genes. PTPRT (protein tyrosine phosphatase receptor-T), a member of the family of type IIB receptor-like PTPs, is the most frequently mutated PTP among them. Consistent with the notion that PTPRT is a tumour suppressor, PTPRT knockout mice are hypersensitive to AOM (azoxymethane)-induced colon cancer. The present review focuses on the physiological and pathological functions of PTPRT as well as the cellular pathways regulated by this phosphatase.
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