Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 79, Issue 1, Pages 11-15Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2014.955455
Keywords
indole diterpene; total synthesis; antimitotic; kinesin spindle protein; terpendole
Ask authors/readers for more resources
The first synthesis of the racemate of terpendole E, a specific inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence that involves diastereoselective installation of its C3 quaternary stereocenter via a cyclopropyl ketone intermediate and Pd-mediated two-step construction of the indole ring moiety as the key transformations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available