Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 79, Issue 4, Pages 636-639Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2014.991683
Keywords
3T3-L1 adipocyte; peroxisome proliferator-activated receptor gamma; perfluorooctanoic acid; adipocyte differentiation
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Funding
- Grants-in-Aid for Scientific Research [15K07440, 24580199] Funding Source: KAKEN
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We examined the effect of perfluorooctanoic acid (PFOA) on adipose cells using 3T3-L1 adipocytes and found that PFOA increased adipocyte differentiation, triglyceride accumulation, and the mRNA level of factors related to adipocyte differentiation. In addition, PFOA bound to peroxisome proliferator-activated receptor gamma (PPAR gamma). These results suggest that PFOA promotes adipocyte differentiation as a PPAR gamma ligand.
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