Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 78, Issue 1, Pages 139-146Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2014.877830
Keywords
obesity; echinoside A; saponin; holothurin A; lipid absorption
Categories
Funding
- National Key Technology Research and Development Program of the Ministry of Science and Technology of China [2012BAD33B07]
- National Natural Science Foundation of China [31000795]
Ask authors/readers for more resources
Two similarly sulfated triterpene saponins from Pearsonothuria graeffei were prepared to investigate the anti-obesity effects of echinoside A (EA) and holothurin A (HA). The in vitro inhibitory activities of EA and HA toward pancreatic lipase were investigated, and two in vivo studies were performed: (i) Male Wistar rats were orally administered the lipid emulsion with or without a saponin (HA or EA). The serum's total triglyceride concentration was measured at various times. (ii) C57BL/6 mice were assigned to four groups, high fat (HF), EA (0.03%), HA (0.04%), and orlistat (0.01%), and the weight of adipose tissue and level of fatty acids excreted in the feces were determined. Both EA and HA repressed the pancreatic lipase activity and increased fatty acid excretion in the feces. Treatment with EA and HA significantly decreased the adipose tissue accumulation in mice. EA and HA manifested different inhibitory activities in vitro, but each of them dramatically inhibited lipid absorption in vivo and showed strong anti-obesity activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available