Journal
AMINO ACIDS
Volume 50, Issue 3-4, Pages 479-485Publisher
SPRINGER WIEN
DOI: 10.1007/s00726-017-2530-2
Keywords
QSAR; QSRR; Antimicrobial lipopeptides; MIC; Hemolysis
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In this study, we investigated the influence of molecular descriptors of cationic lipopeptides on their antimicrobial activity and hemolytic properties. The quantitative structure-activity relationship and quantitative structure-property relationship models were constructed. The antimicrobial, hemolytic and retention data were used as dependent variable and structural parameters as the independent ones. The obtained results suggest that the chromatographic indexes can be employed for prediction of antibacterial activity and that lipopeptides present nonspecific interaction between erythrocytes and bacterial membranes.
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