Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 5, Pages 3420-3425Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am509161y
Keywords
tetraphenylethene (TPE); poly(N-isoproylacryamide); (PNIPAM); fluorescent organic nanopartices; aggregation-induced emission (AIE); long-term celluar tracing
Funding
- National Natural Science Foundation of China [20902031, 81372400, J1103514]
- National Basic Research Program [2012CB932500, 2015CB931800]
- Fundamental Research Funds for the Central Universities [HUST 2013YGYL003]
- Natural Science Foundation of Hubei Province [2013CFB163]
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Temperature-sensitive organic nanoparticles with AIE effect were assembled in water from tetraphenylethene-based poly(N-isopropylacrylamide) (TPE-PNIPAM), which was synthesized by ATRP using TPE derivative as initiator. The size and fluorescence of TPE-PNIPAM nanoparticles can be tuned by varying the temperature. These nanoparticles can be internalized readily by HeLa cells and can be used as long-term tracer in live cells to be retained for as long as seven passages.
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