Journal
AMERICAN JOURNAL ON ADDICTIONS
Volume 27, Issue 2, Pages 71-91Publisher
WILEY
DOI: 10.1111/ajad.12674
Keywords
Brain Stimulation; Non-Invasive; Tobacco; Alcohol; Cannabis; Opioids; Stimulants; Transcranial Direct Current Stimulation (tDCS); Repetitive Transcranial Magnetic Stimulation (rTMS); Deep Brain Stimulation (DBS)
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Funding
- Canadian Institutes of Health Research (CIHR) grant MOP [115145]
- Chair in Addiction Psychiatry at the University of Toronto
- NIDA [1R21-DA-043949]
- NATIONAL INSTITUTE ON DRUG ABUSE [R21DA043949] Funding Source: NIH RePORTER
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BackgroundSubstance use disorders (SUDs) are a leading cause of disability worldwide. While several pharmacological and behavioral treatments for SUDs are available, these may not be effective for all patients. Recent studies using non-invasive neuromodulation techniques including Repetitive Transcranial Magnetic Stimulation (rTMS), Transcranial Direct Current Stimulation (tDCS), and Deep Brain Stimulation (DBS) have shown promise for SUD treatment. ObjectiveMultiple studies were evaluated investigating the therapeutic potential of non-invasive brain stimulation techniques in treatment of SUDs. MethodThrough literature searches (eg, PubMed, Google Scholar), 60 studies (2000-2017) were identified examining the effect of rTMS, tDCS, or DBS on cravings and consumption of SUDs, including tobacco, alcohol, cannabis, opioids, and stimulants. ResultsrTMS and tDCS demonstrated decreases in drug craving and consumption, while early studies with DBS suggest similar results. Results are most encouraging when stimulation is targeted to the Dorsolateral Prefrontal Cortex (DLPFC). ConclusionsShort-term treatment with rTMS and tDCS may have beneficial effects on drug craving and consumption. Future studies should focus on extending therapeutic benefits by increasing stimulation frequency and duration of treatment. Scientific SignificanceThe utility of these methods in SUD treatment and prevention are unclear, and warrants further study using randomized, controlled designs. (Am J Addict 2018;27:71-91)
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