Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 77, Issue 5, Pages 1100-1103Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.120925
Keywords
Alzheimer's disease; amyloid beta; aggregation; (+)-taxifolin; silymarin
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [21248015, 22603006, 22.4068]
- Asahi Group Foundation
- Kato Memorial Bioscience Foundation
- Grants-in-Aid for Scientific Research [21248015, 22603006] Funding Source: KAKEN
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Silymarin, the seed extract of Silybium marianum, has preventive effects against Alzheimer's disease-like pathogenesis in vivo. We isolated (+)-taxifolin (4) from silymarin as an inhibitor of aggregation of the 42-residue amyloid beta-protein. Structure-activity relationship studies revealed the 3',4'-dihydroxyl groups to be critical to the anti-aggregative ability, whereas the 7-hydroxyl group and the stereochemistry at positions 2 and 3 were not important.
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