Journal
PHYSIOLOGICAL RESEARCH
Volume 67, Issue -, Pages S267-S279Publisher
ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
DOI: 10.33549/physiolres.933975
Keywords
Cell-penetrating peptides; Cell penetration; Peptides; Drug delivery
Categories
Funding
- Ministry of Education, Youth and Sports of CR within the National Sustainability Program I (NPU I) [POLYMAT LO1507]
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Cell-penetrating compounds are substances that enhance the cellular uptake of various molecular cargoes that do not easily cross the cellular membrane. The majority of cell-penetrating compounds described in the literature are cell-penetrating peptides (CPPs). This review summarizes the various structural types of cell-penetrating compounds, with the main focus on CPPs. The authors present a brief overview of the history of CPPs, discuss the various types of conjugation of CPPs to biologically active cargoes intended for cell internalization, examine the cell-entry mechanisms of CPPs, and report on the applications of CPPs in research and in preclinical and clinical studies.
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