Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 76, Issue 4, Pages 825-827Publisher
OXFORD UNIV PRESS
DOI: 10.1271/bbb.110751
Keywords
Berberis koreana; Berberidaceae; steroid; itesmol 3-O-palmitate; cytotoxicity
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Funding
- Korea Research Foundation (KRF)
- Korean Government (MOEHRD) [KRF-E00739]
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A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (respective IC50 values of 7.41, 9.20, 4.53, and 12.91 mu m).
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