Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 75, Issue 9, Pages 1832-1834Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.110235
Keywords
Aspergillus oryzae; LaeA; kojic acid
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- New Energy and Industrial Technology Development Organization (NEDO) of Japan
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Kojic acid synthesis genes regulation was investigated in Aspergillus oryzae. Our results indicate that kojic acid production was lost in the laeA disruption strain, but was recovered in the LaeA complement strain. Real-time PCR also confirmed that expression of kojic acid biosynthesis genes decreased in the laeA disruption strain, indicating that these genes are under the control of LaeA.
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