Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 75, Issue 2, Pages 208-213Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.100684
Keywords
vitamin D3; 25-hydroxy vitamin D3 1alpha-hydroxylase (1 alpha(OH)ase); vitamin D receptor (VDR); VDR interacting repressor (VDIR); epigenetic regulation
Categories
Funding
- Japan Society for the Promotion of Science (JSPS)
Ask authors/readers for more resources
Vitamin D has a pivotal role in a many biological processes, including the maintenance of calcium homeostasis, cell differentiation and proliferation. Most of these actions are mediated by transcriptional regulation of target genes through vitamin D receptor (VDR), a member the steroid/thyroid hormone receptor superfamily. Thus, it is important to understand vitamin D biosynthesis into an active form that regulates VDR transcriptional functions. The active form of vitamin D, 1 alpha,25(OH)(2)D-3, derived by vitamin D-3 1alpha hydroxylase, 1 alpha(OH)ase in renal proximal tubule cells is a ligand for VDR. We have identified the 1 alpha(OH)ase gene, which uses a novel expression cloning method derived from VDR deficient mice that have excess amounts of active vitamin D-3 in the serum. Identification of 1 alpha(OH)ase gene had lead us to understand not only the biological significance of active vitamin D-3 synthesis, but also a novel mechanism of VDR-mediated transcriptional regulation. The gene expression of 1 alpha(OH)ase is positively and negatively regulated by parathyroid hormone (PTH) and active vitamin D-3 respectively. In this review, we describe switching between positive and negative transcriptional modulation by the VDR, together with recent findings on the mechanisms of VDR-mediated epigenetic regulation in the 1 alpha(OH)ase gene.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available