Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 74, Issue 10, Pages 2096-2099Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.100193
Keywords
proline-hydroxyproline (Pro-Hyp); hyaluronic acid; collagen hydrolysates; osteoarthritis; proteoglycan
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Funding
- Grants-in-Aid for Scientific Research [22590498] Funding Source: KAKEN
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Proline-hydroxyproline (Pro-Hyp) stimulated hyaluronic acid production in cultured synovium cells. It was detected in guinea pig blood after oral ingestion of collagen hydrolysates. Oral administration of collagen hydrolysates increased the amount of proteoglycans in the epiphyses. It also reduced the morphological changes associated with osteoarthritic cartilage destruction of the knee joint. The results suggest that collagen hydrolysates have therapeutic potential for treatment of osteoarthritis.
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