Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 74, Issue 2, Pages 279-284Publisher
OXFORD UNIV PRESS
DOI: 10.1271/bbb.90582
Keywords
Leonurus sibiricus herb; LOX-1; adhesion molecules; C57BL/6 mice; human umbilical vein endothelial cells
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Funding
- Dongguk University Research Fund
- MOST/KOSEF [R13-2005-013-01000-0]
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In Leonurus sibiricus herb extract (LHE)-supplemented animals, plasma cholesterol decreased and high-density lipoprotein-cholesterol increased, resulting in a lowered atherogenic index. The plasma trolox equivalent antioxidant capacity, levels of hepatic thiobarbituric acid-reactive substances, and protein carbonyl values decreased significantly in LHE-supplemented mice (p < 0.05), whereas the hepatic antioxidant indicators were all significantly elevated (p < 0.05). In human umbilical vein endothelial cells stimulated with tumor necrosis factor alpha, LHE significantly suppressed intracellular reactive oxygen species, LOX-1, and adhesion molecules. LHE supplementation may modulate the lipoprotein composition and attenuate oxidative stress by elevated antioxidant processes, thus suppressing the activation of inflammatory mediators. This is a possible mechanism of the anti-atherogenic effect.
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