Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 74, Issue 6, Pages 1302-1305Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.100082
Keywords
post-translational modification; SUMO; protein interaction; histone methyltransferase; chromatin
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Funding
- Naito Foundation
- Japanese Ministry of Education, Culture, Sports, Science, and Technology
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SUMO-interacting motifs (SIMs) play a central role in the fate of SUMO-modified proteins. Here we report a real-time SUMO-binding assay. It can be applied to the identification of SIMs and to screening for the identification of novel SUMO-binding proteins. Using this assay, we investigated the SIMs in SETDB1 and MCAF1 to gain insight into the assembly of SETDB1-MCAF1-mediated gene silencing.
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