Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 73, Issue 7, Pages 1679-1682Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.90114
Keywords
yeast based assay; Boesenbergia pandurata; pinostrobin; Ca2+ signal; inhibitor
Categories
Funding
- Thailand Research Fund [DBG4880005]
- 90th Anniversary of Chulalongkorn University Fund
- Hitachi Scholarship Foundation
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Upon searching plant extracts for inhibitors of the Ca2+ signaling pathway using the zds1 Delta-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as active components. Further biochemical experiments confirmed that pinostrobin possesses inhibitory activity on the Ca2+ signals involved in the control of G2/M phase cell cycle progression in Saccharomyces cerevisiae.
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