Surugapyrroles A and B, Two New N-Hydroxypyrroles, as DPPH Radical-Scavengers from Streptomyces sp USF-6280 Strain

Two new N-hydroxypyrroles, surugapyrroles A and B, were isolated as DPPH radical-scavengers from a culture broth of Streptomyces sp. USF-6280 strain. The structures of the two compounds were elucidated by spectroscopic evidences and derivatization. Their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical-scavenging activity was as high as that of butylhydroxytoluene (BHT): surugapyrrole A, ED50 50.3 mu M; surugapyrrole B, ED50 75.8 mu M.