Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 72, Issue 11, Pages 3038-3040Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.80426
Keywords
circadian rhythm; resveratrol; Rat-1 cells
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Circadian clocks, especially peripheral clocks, can be strongly entrained by daily feedings, but few papers have reported the effects of food components on circadian rhythm. The effects of resveratrol, a natural polyphenol, on circadian clocks of Rat-1 cells were analyzed. A dose of 100 Km resveratrol, which did not show cytotoxicity, regulated the expression of clock genes Per1, Per2, and Bmal1.
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