Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 72, Issue 11, Pages 2992-2997Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.80562
Keywords
Cortisium simplex; cortistatin A; synthesis; HUVEC; angiogenesis
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Funding
- Japan Society for the Promotion of Science [19580120]
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Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.
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