Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 72, Issue 12, Pages 3293-3296Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.80445
Keywords
lactobacilli; lipid rafts; tumor necrosis factor-alpha
Categories
Funding
- CONICET [PIP 6248, PIP 6249]
- Agencia Nacional de Promocion Cientifica y Tecnologica [PICT 15016-BID, 1728/OC-AR]
- CIUNT [D-303]
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We investigated, to determine whether disruption of lipid rafts would influence the effect of three selected strains of Lactobacillus on TNF-alpha production by peripheral blood mononuclear cells. Two strains increased TNF-alpha production; and the third one reduced cytokine levels. Disruption of rafts changed the immunomodulatory effect of the three strains. This is the first report on a potential role of rafts in lactobacilli-cell interaction.
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