Journal
BIOMEDICAL MATERIALS
Volume 13, Issue 4, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1748-605X/aab523
Keywords
macrophages; mineralized collagen; hydroxyapatite; polarization; immune cell
Funding
- Chinese National Key Research and Development Program [2016 YFB0700802]
- Intergovernmental cooperation in science and technology [2016YFE0125300]
- Key Laboratory of Advanced Materials of Ministry of Education [2017AML12]
- Natural Science Foundation of Liaoning Province [2015-B-000002015020483]
- Joint Education postgraduates Programs [2016-B]
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Understanding the interaction between biomaterials and the immune system has become increasingly important. Mineralized collagen (MC) has the same chemical components and microstructures to natural bone tissue, and is considered as a better biomaterial for bone prostheses compared to hydroxyapatite (HA). However, there is little information about how MC affects inflammatory responses. In this study, we investigate the inflammatory responses to MC and HA by culturing RAW264.7 cells on their surfaces. We observed that MC increases CD206+ staining and IL-10 (M2 macrophages), whereas HA shows cells expressing more CD86 and secreting more TNF-alpha. This result indicates that MC may attenuate inflammatory responses to implanted bone prostheses.
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