Journal
JOURNAL OF FUNGI
Volume 4, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/jof4010022
Keywords
epithelial cell; Candida; fungus; mucosal infection; commensalism; pathogenicity; microbiota
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/N014677/1]
- Medical Research Council [MR/M011372/1]
- National Institute for Health Research at Guys and St Thomas's NHS Foundation Trust and King's College London Biomedical Research Centre [IS-BRC-1215-20006]
- Rosetrees Trust [M680]
- National Institutes of Health [R37-DE022550]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R37DE022550] Funding Source: NIH RePORTER
- BBSRC [BB/N014677/1] Funding Source: UKRI
- MRC [MR/J008303/1, MR/M011372/1] Funding Source: UKRI
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A plethora of intricate and dynamic molecular interactions occur between microbes and the epithelial cells that form the mucosal surfaces of the human body. Fungi, particularly species of Candida, are commensal members of our microbiota, continuously interacting with epithelial cells. Transient and localised perturbations to the mucosal environment can facilitate the overgrowth of fungi, causing infection. This minireview will examine the direct and indirect mechanisms by which Candida species and epithelial cells interact with each other, and explore the factors involved in the central processes of adhesion, invasion, and destruction of host mucosal surfaces.
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