Journal
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 54, Issue 2, Pages -Publisher
UNIV SAO PAULO, CONJUNTO QUIMICAS
DOI: 10.1590/s2175-97902018000217363
Keywords
Crataegus pentaegyna; Crataegus microphylla; Antihypoxia/evaluation; Circulatory hypoxia
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The aim of this study was to evaluate anti-hypoxia activity of polyphenolic extracts of Crataegus microphylla and Crataegus pentaegyn on mice. Three experimental models of hypoxia were considered, including asphyctic hypoxia, haemic hypoxia, and circulatory hypoxia. Polyphenolic extract of both plants exhibited significant anti-hypoxic activity and prolonged animal survival time. Anti-hypoia activity of C. pentaegyn was found to be superior to that of C. microphylla in circulatory and asphyctic hypoxia. Antihypoxic activity of these extracts may be attributed to their phenolic compounds.
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