Journal
CHEMICAL RECORD
Volume 18, Issue 7-8, Pages 849-857Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201700078
Keywords
Clays; DNA; Sepiolite; Mammalian Cell transfection
Categories
Funding
- La Ligue Nationale Contre le Cancer
- ANR (Agence Nationale de la Recherche) [ANR-14-CE10-0010-02, ANR-16-CE18-0012-02]
- AFM-Telethon
- INCa (Institut National du Cancer) [2013-1-PLBIO-14]
- MINECO, Spain [MAT2012-31759, MAT2015-71117-R]
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Sepiolite is a nanofibrous natural silicate that can be used as a nanocarrier for DNA transfer thanks to its strong interaction with DNA molecules and its ability to be naturally internalized into mammalian cells through both non-endocytic and endocytic pathways. Sepiolite, due to its ability to bind various biomolecules, could be a good candidate for use as a nanocarrier for the simultaneous vectorization of diverse biological molecules. In this paper, we review our recent work, issued from a starting collaboration with Prof. Ruiz-Hitzky, that includes diverse aspects on the characterization and main features of sepiolite/DNA nanohybrids, and we present an outlook for the further development of sepiolite for DNA transfer.
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