Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 5, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2018.1445941
Keywords
autophagy; exosomes; V1V0-ATPase; acidification; metastasis; biology of malignant cells; mechanisms of oncogenesis and tumor progression
Categories
Funding
- National Sciences and Engineering Research Council of Canada [436104]
- Canadian Cancer Society Research Institute (CCSRI) [702978]
- Fondation France Alzheimer
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Autophagy-related-5 (Atg5) and Autophagy-related-16-Like-1 (Atg16L1) canonically participate in autophagy. Recent research demonstrates that apart from this, they also control production of extracellular vesicles called exosomes by regulating acidification of late endosomes. Atg5-mediated exosome production increased migration and metastasis of breast cancer cells suggesting exosomes may perform some functions ascribed to autophagy.
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