Journal
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
Volume 5, Issue 3, Pages 289-298Publisher
ELSEVIER INC
DOI: 10.1016/j.jcmgh.2017.12.004
Keywords
3D Organoids; Pancreas; Adenocarcinoma; Personalized Medicine
Categories
Funding
- NATIONAL CANCER INSTITUTE [F30CA180601] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK050306, R01DK060694, P30DK019525] Funding Source: NIH RePORTER
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Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the third leading cause of cancer-related mortality in the United States. Although important advances have been made in the last decade, the mortality rate of pancreatic ductal adenocarcinoma has not changed appreciably. This review summarizes a rapidly emerging model of pancreatic cancer research, focusing on 3-dimensional organoids as a powerful tool for several applications, but above all, representing a step toward personalized medicine.
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