Journal
METABOLITES
Volume 8, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/metabo8010010
Keywords
pregnancy; human; placenta; metabolomics; H-1-NMR
Categories
Funding
- NIH [TL1TR001428, T32HL083810]
- Georgia Research Alliance
- University of Georgia Office of Research
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR001427, TL1TR001428] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL083810] Funding Source: NIH RePORTER
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We evaluated the metabolic alterations in maternal and fetal placental tissues from non-labored women undergoing cesarean section using samples collected from 5 min to 24 h following delivery. Using H-1-NMR, we identified 14 metabolites that significantly differed between maternal and fetal placental tissues (FDR-corrected p-value < 0.05), with 12 metabolites elevated in the maternal tissue, reflecting the flux of these metabolites from mother to fetus. In the maternal tissue, 4 metabolites were significantly altered at 15 min, 10 metabolites at 30 min, and 16 metabolites at 1 h postdelivery, while 11 metabolites remained stable over 24 h. In contrast, in the fetal placenta tissue, 1 metabolite was significantly altered at 15 min, 2 metabolites at 30 min, and 4 metabolites at 1 h postdelivery, while 22 metabolites remained stable over 24 h. Our study provides information on the metabolic profiles of maternal and fetal placental tissues delivered by cesarean section and reveals that there are different metabolic alterations in the maternal and fetal tissues of the placenta following delivery.
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