Journal
BIORESOURCE TECHNOLOGY
Volume 136, Issue -, Pages 761-765Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2013.03.134
Keywords
Quorum sensing; Homoserine lactone; Pollutant biodegradation; Pseudomonas aeruginosa; Aromatics
Funding
- National Natural Science Foundation of China (NSFC) [30821005, 20876096]
- National Basic Research Program of China (973 Program) [2009CB118906]
- Shanghai Leading Academic Discipline Project [B203, B505]
- Jiangsu University [12JDG072]
- 'Six Talent Peaks' program (Jiangsu Province, China) [2012-NY-029]
- Priority Program Development of Jiangsu Higher Education Institutions
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The mechanism for quorum sensing (QS) regulation on aromatics degradation was investigated. Deletion of rhl QS system resulted in a significant decrease in aromatics biodegradation as well as the activity of catechol 2,3-dioxygenase (C23O, key enzyme for catechol meta-cleavage pathway) in Pseudomonas aeruginosa CGMCC1.860. Interestingly, this repression could be relieved by N-butyryl homoserine lactone (the signaling molecule of rhl QS system) addition. In accordance, the transcription level of nahH (the gene encoding C23O) and nahR (transcriptional activator) also responded to rhl perturbation in a similar way. The results indicated that rhl QS system positively controlled the catechol meta-cleavage pathway, and hence improved aromatics biodegradation. It suggested manipulation of QS system could be a promising strategy to tune the catechol cleavage pathway and to control aromatics biodegradation. (C) 2013 Elsevier Ltd. All rights reserved.
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