Quantifying Inhibitory Control as Externalizing Proneness: A Cross-Domain Model

Recent mental health initiatives have called for a shift away from purely report-based conceptualizations of psychopathology toward a biobehaviorally oriented framework. The current work illustrates a measurement-oriented approach to challenges inherent in efforts to integrate biological and behavioral indicators with psychological-report variables. Specifically, we undertook to quantify the construct of inhibitory control (inhibition-disinhibition) as the individual difference dimension tapped by self-report, task-behavioral, and brain response indicators of susceptibility to disinhibitory problems (externalizing proneness). In line with prediction, measures of each type cohered to form domain-specific factors, and these factors loaded in turn onto a cross-domain inhibitory control factor reflecting the variance in common among the domain factors. Cross-domain scores predicted behavioral-performance and brain-response criterion measures as well as clinical problems (i.e., antisocial behaviors and substance abuse). Implications of this new cross-domain model for research on neurobiological mechanisms of inhibitory control and health/performance outcomes associated with this dispositional characteristic are discussed.