Journal
COST EFFECTIVENESS AND RESOURCE ALLOCATION
Volume 16, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12962-018-0158-z
Keywords
Coronary bypass surgery; Percutaneous coronary intervention; Cost-benefit analysis; Bootstrap method; Bare metal stent
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Funding
- Zerbini Foundation, Sao Paulo, Brazil
- Medical School of the University of Sao Paulo
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BackgroundThe costs for treating coronary artery disease (CAD) are high worldwide. We performed a prespecified analyses of cost-effectiveness of three therapeutic strategies for multivessel CAD.MethodsFrom May 1995 to May 2000, a total of 611 patients were randomly assigned to coronary artery bypass graft (CABG), n=203; percutaneous coronary intervention (PCI), n=205; or medical treatment (MT), n=203. This cost analysis study was based on the perspective of the Public Health Care System. Initial procedural and follow-up costs for medications, cardiology examinations, and hospitalizations for complications were calculated after randomization. Life-years and quality-adjusted life years (QALYs) were used as effectiveness measures. Incremental cost-effectiveness ratios (ICER) were obtained by using nonparametric bootstrapping methods with 5000 resamples.ResultsInitial procedural costs were lower for MT. However, the subsequent 5-year cumulative costs were lower for CABG. Compared with baseline, the three treatment options produced significant improvements in QALYs. After 5years, PCI and CABG had better QALYs results compared with MT. The ICER results favored CABG and PCI, and favored PCI over CABG in 61% of the drawings. On the other hand, sensitivity analysis showed MT as the preferred therapy compared with CABG and PCI, in the analysis considering higher costs.ConclusionsAt 5-year follow-up, the three treatment options yielded improvements in quality of life, with comparable and acceptable costs. However, despite higher initial costs, the comparison of cost-effectiveness after 5years of follow-up among the three treatments showed both interventions (CABG and PCI) to be cost-effective strategies compared with MT.Trial registration ISRCTN, ISRCTN66068876, Registered 06/10/1994, http://www.controlled-trials.com/ISRCTN66068876
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