Journal
BIOFACTORS
Volume 44, Issue 1, Pages 36-49Publisher
WILEY
DOI: 10.1002/biof.1399
Keywords
resveratrol; oxidative stress; cellular defense system; SIRT1; Nrf2
Funding
- Basic Science Research Program through the National Research Foundation of Korea [NRF-2014R1A2A1A11050006, NRF-2017R1D1A1B03031112]
Ask authors/readers for more resources
Resveratrol, a natural polyphenolic compound, is found in various kinds of fruits, plants, and their commercial products such as red wine. It has been demonstrated to exhibit a variety of health-promoting effects including prevention and/or treatment of cardiovascular diseases, inflammation, diabetes, neurodegeneration, aging, and cancer. Cellular defensive properties of resveratrol can be explained through its ability of either directly neutralizing reactive oxygen species/reactive nitrogen species (ROS/RNS) or indirectly upregulating the expression of cellular defensive genes. As a direct antioxidant agent, resveratrol scavenges diverse ROS/RNS as well as secondary organic radicals with mechanisms of hydrogen atom transfer and sequential proton loss electron transfer, thereby protecting cellular biomolecules from oxidative damage. Resveratrol also enhances the expression of various antioxidant defensive enzymes such as heme oxygenase 1, catalase, glutathione peroxidase, and superoxide dismutase as well as the induction of glutathione level responsible for maintaining the cellular redox balance. Such defenses could be achieved by regulating various signaling pathways including sirtuin 1, nuclear factor-erythroid 2-related factor 2 and nuclear factor B. This review provides current understanding and information on the role of resveratrol in cellular defense system against oxidative stress. (c) 2017 BioFactors, 44(1):36-49, 2018
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available