Journal
BIOACTIVE MATERIALS
Volume 3, Issue 3, Pages 347-354Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2018.05.003
Keywords
Gold nanorods; Doxorubicin; pH responsive; Photothermal therapy; Combinational therapy
Funding
- National Key Research and Development Program of China [2016YFB0700804]
- National Natural Science Foundation of China [51673171]
- Zhejiang Provincial Natural Science Foundation of China [LR16E030001, LR15H160001]
- Fundamental Research Funds for the Central Universities of China [2018QNA4057]
- Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, P. R. China/Women's Reproductive Health Key Laboratory of Zhejiang Province/Uterine Tumors Research Center of Zhejiang Province [ZDFY2017-RG/RH-001]
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Cancer chemotherapy can be hindered by drug resistance which leads to lower drug efficiency. Here, we have developed a drug delivery system that tethers doxorubicin to the surface of gold nanorods via a pH-sensitive linkage (AuNRs@DOX), for a combined photothermal and chemical therapy for cancer. First, AuNRs@DOX is ingested by HepG2 liver cancer cells. After endocytosis, the acidic pH triggers the release of doxorubicin, which leads to chemotherapeutic effects. The gold nanorods are not only carriers of DOX, but also photothermal conversion agents. In the presence of an 808 nm near-infrared laser, AuNRs@DOX significantly enhance the cytotoxicity of doxorubicin via the photothermal effect, which induces elevated apoptosis of hepG2 cancer cells, leading to better therapeutic effects in vitro and in vivo. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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