Journal
CLINICAL AND TRANSLATIONAL MEDICINE
Volume 7, Issue -, Pages -Publisher
SPRINGEROPEN
DOI: 10.1186/s40169-018-0202-9
Keywords
YAP; TAZ; Hippo pathway; Mechanotransduction; Contact inhibition of proliferation; Actomyosin; Cancer progression; Cancer therapy resistance
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Funding
- Nagoya University [2614Dj-02b]
- R-Pharm [2614Dj-02b]
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Yes-associated protein (YAP) and its paralog WW domain containing transcription regulator 1 (TAZ) are important regulators of multiple cellular functions such as proliferation, differentiation, and survival. On the tissue level, YAP/TAZ are essential for embryonic development, organ size control and regeneration, while their deregulation leads to carcinogenesis or other diseases. As an underlying principle for YAP/TAZ-mediated regulation of biological functions, a growing body of research reveals that YAP/TAZ play a central role in delivering information of mechanical environments surrounding cells to the nucleus transcriptional machinery. In this review, we discuss mechanical cue-dependent regulatory mechanisms for YAP/TAZ functions, as well as their clinical significance in cancer progression and treatment.
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