Journal
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
Volume 66, Issue 3, Pages 183-197Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00005-017-0494-2
Keywords
DEHP; Tumorigenesis; Nuclear receptors; Redox homeostasis; Epigenetic modifications; Chemoresistance
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Funding
- National Science Council, Taiwan [NSC102-2632-B-037-001-MY3, MOST105-2311-B-037-001, MOST106-2320-B-037-012]
- Ministry of Science and Technology, Taiwan
- grant Aim for the Top Universities Grant [KMU-TP103A17, KMU-TP104A3, KMU-TP105A07]
- NSYSU-KMU Joint Research Project, Kaohsiung Medical University, Taiwan [NSYSU-KMU105-P017, NSYSU-KMU106-P019]
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Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet, the leaching of DEHP from PVC-based consumables ultimately results in the deposition in certain tissues via inadvertent applications. Health risks for human populations exposed to DEHP has been assumed by studies on rodents and other species, including the DEHP-induced developmental dysregulation, reproductive impairments, tumorigenesis, and diseases in a transgenerational manner. In this review, we comprehensively summarize the accumulated literature regarding the multifaceted roles of DEHP in the activation of the nuclear receptors, the alteration of the redox homeostasis, epigenetic modifications and the acquisition of chemoresistance.
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