Journal
BIOACTIVE MATERIALS
Volume 3, Issue 1, Pages 1-18Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2018.01.001
Keywords
Graphene; Hydroxyapatite; Composites; Bone tissue; Biomedical devices
Funding
- National Natural Science Foundation of China [31370954, 31670974]
- Beijing Natural Science Foundation [2164073]
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Hydroxyapatite (HA) is an attractive bioceramic for hard tissue repair and regeneration due to its physicochemical similarities to natural apatite. However, its low fracture toughness, poor tensile strength and weak wear resistance become major obstacles for potential clinical applications. One promising method to tackle with these problems is exploiting graphene and its derivatives (graphene oxide and reduced graphene oxide) as nanoscale reinforcement fillers to fabricate graphene-based hydroxyapatite composites in the form of powders, coatings and scaffolds. The last few years witnessed increasing numbers of studies on the preparation, mechanical and biological evaluations of these novel materials. Herein, various preparation techniques, mechanical behaviors and toughen mechanism, the in vitro/in vivo biocompatible analysis, antibacterial properties of the graphene-based HA composites are presented in this review. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
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