Journal
NATURAL PRODUCTS AND BIOPROSPECTING
Volume 8, Issue 6, Pages 419-430Publisher
SPRINGER SINGAPORE PTE LTD
DOI: 10.1007/s13659-018-0180-z
Keywords
Piper mullesua; Piperaceae; Antiplatelet; Amides; Isoquinoline alkaloids
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Funding
- Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences [Y4ZK111B01]
- Natural Science Foundation of Yunnan Province, China [2011FZ205]
- International Partneship Program of Chinese Academy of Sciences [153631KYSB20160004]
- Key Laboratory of Ethnomedicine (Minzu University of China) of Ministry of Education of China [KLEM-ZZ201806]
- National Natural Science Foundation of China [31761143001, 31161140345]
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One undescribedamide, pipermullesine A, twoundescribed isoquinoline alkaloids, pipermullesinesBand C, and six undescribed dipeptides, pipermullamides A-F, along with 28 known compounds, were isolated from the aerial parts of Piper mullesua. The structures of the undescribed compounds were elucidated based on the analysis of 1D and 2D NMR and MS data. Furthermore, the structures of pipermullesines A-Cwere confirmed by single crystal X-ray diffraction analysis. All isolates were evaluated for inhibitory activity against platelet aggregation induced by thrombin (IIa) or platelet-activating factor (PAF). (-)-Mangochinine, pellitorine, and (2E, 4E)-N-isobutyl-2,4-dodecadienamide showed weak inhibitory activity against rabbit platelet aggregation induced by PAF, with IC50 values of 470.3 mu g/mL, 614.9 mu g/mL, and 579.7 mu g/mL, respectively.
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