Journal
BONE RESEARCH
Volume 6, Issue -, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41413-017-0004-5
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Funding
- National Key R&D Program of China [2016YFC1100203]
- Priority Academic Program Development of Jiangsu High Education Institutions (PAPD)
- National Natural Science Foundation of China [81772294]
- NIH [R01 AR060456, R01 AR055923]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR060456, R01AR055923] Funding Source: NIH RePORTER
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The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that integrates inputs from nutrients and growth factors to control many fundamental cellular processes through two distinct protein complexes mTORC1 and mTORC2. Recent mouse genetic studies have established that mTOR pathways play important roles in regulating multiple aspects of skeletal development and homeostasis. In addition, mTORC1 has emerged as a common effector mediating the bone anabolic effect of Igf1, Wnt and Bmp. Dysregulation of mTORC1 could contribute to various skeletal diseases including osteoarthritis and osteoporosis. Here we review the current understanding of mTOR signaling in skeletal development and bone homeostasis, as well as in the maintenance of articular cartilage. We speculate that targeting mTOR signaling may be a valuable approach for treating skeletal diseases.
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