Journal
BIORESOURCE TECHNOLOGY
Volume 99, Issue 11, Pages 5145-5149Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2007.09.013
Keywords
antifungal activity; cinnamaldehyde; eugenol; Laetiporus sulphureus; Lenzites betulina
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In this study, the antifungal activities of cinnamaldehyde and eugenol congeners against white-rot fungus Lenzites betulina and brown-rot fungus Laetiporus sulphureus were evaluated and the relationships between the antifungal activity and the chemical structures were also examined. Results from antifungal tests revealed that cinnamaldehyde, alpha-methyl cinnamaldehyde, (E)-2-methylcinnamic acid, eugenol and isoeugenol exhibited strong antifungal activity against all fungi tested. Results derived from the chemical structure-antifungal activity relationship study suggested that compounds with an aldehyde group or an acid group, a conjugated double bond and a length of CH chain outside the ring affect their antifungal properties. Furthermore, the presence of the methyl moiety in the ortho position may have a considerable influence on the inhibitory action against L. betulina and L. sulphureus. In addition, the lipophilicity may play, in part, a crucial role in determining the toxicity of phenylpropenes. (C) 2007 Elsevier Ltd. All rights reserved.
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