Journal
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Volume 33, Issue 9, Pages 1077-1085Publisher
SPRINGER
DOI: 10.1007/s00449-010-0433-7
Keywords
Propionic acid; Propionibacterium freudenreichii CCTCC M207015; Multi-point fibrous-bed (MFB) bioreactor; Fed-batch fermentation
Funding
- National Basic Research Program of China (973) [2007CB714304]
- National High Technology Research and Development Program of China [2009AA033004]
- Jiangsu Key Technology Research and Development Program [BE2009363]
- Jiangsu Postdoctoral Sustentation Fundation [0901011C]
- University Nature Science Research Project of Jiangsu Province [09KJB530007]
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Propionic acid was produced in a multi-point fibrous-bed (MFB) bioreactor by Propionibacterium freudenreichii CCTCC M207015. The MFB bioreactor, comprising spiral cotton fiber packed in a modified 7.5-l bioreactor, was effective for cell-immobilized propionic acid production compared with conventional free cell fermentation. Batch fermentations at various glucose concentrations were investigated in the MFB bioreactor. Based on analysis of the time course of production, a fed-batch strategy was applied for propionic acid production. The maximum propionic acid concentration was 67.05 g l(-1) after 496 h of fermentation, and the proportion of propionic acid to total organic acids was approximately 78.28% (w/w). The MFB bioreactor exhibited excellent production stability during batch fermentation and the propionic acid productivity remained high after 78 days of fermentation.
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