Journal
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume 59, Issue 14, Pages -Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.17-23750
Keywords
dry eye; ocular surface; Sjogren's syndrome; non-Sjogren's syndrome; chronic GVHD
Categories
Funding
- Japanese Ministry of Education, Science, Sports, Culture and Technology [23592590, 26462668, 18K09421]
- Japanese Ministry of Health, Labour and Welfare of Japan Labour Sciences Research Grants for Research on Intractable Diseases (The Research Team for Autoimmune Diseases)
- Dry Eye Society, Tokyo, Japan
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I have reviewed available literature on dry eye related to Sjogren's syndrome (SS), non-Sjogren's syndrome (non-SS), and graft-versus-host disease (GVHD) to examine aqueous tear deficient dry eye as a subtype of dry eye. This section will focus on clinical studies regarding those subtypes of dry eye. I searched the PubMed database from 1990-2017 for discussion of clinical features, diagnostic criteria, and risk factors of SS, non-SS, and GVHD-related dry eye. In addition, therapeutic options for each subtype of dry eye are described. Although the clinical presentations of SS and chronic graft-versus-host disease (cGVHD) are similar, ocular surface fibrotic changes are characteristic of ocular GVHD but not SS-or non-SS-related dry eye. Recently, diagnostic criteria for each disease have been proposed and include the American College of Rheumatology/European League Against Rheumatism (ACR-EULAR) for SS and the International Chronic Ocular GVHD consensus criteria. Although there has been gradual progress, there are currently no specific therapies and few approved treatment options for these intractable diseases, including SS and GVHD. As judged by the findings, these subtypes of dry eye are different clinical entities from simple dry eye. Therefore, novel therapies, specific to these subtypes of dry eye, may be required in the future.
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