Journal
BIOPOLYMERS
Volume 101, Issue 8, Pages 821-833Publisher
WILEY
DOI: 10.1002/bip.22486
Keywords
biocompatible; biodegradable; catgut; extracellular matrix; regenerative medicine
Categories
Funding
- NIH [R01 AR044276, RC2 AR058971]
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With its wide distribution in soft and hard connective tissues, collagen is the most abundant of animal proteins. In vitro, natural collagen can be formed into highly organized, three-dimensional scaffolds that are intrinsically biocompatible, biodegradable, nontoxic upon exogenous application, and endowed with high tensile strength. These attributes make collagen the material of choice for wound healing and tissue engineering applications. In this article, we review the structure and molecular interactions of collagen in vivo; the recent use of natural collagen in sponges, injectables, films and membranes, dressings, and skin grafts; and the on-going development of synthetic collagen mimetic peptides as pylons to anchor cytoactive agents in wound beds. (C) 2014 Wiley Periodicals, Inc.
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