Journal
BIOPOLYMERS
Volume 99, Issue 4, Pages 239-244Publisher
WILEY
DOI: 10.1002/bip.22163
Keywords
excluded volume; steric repulsion; weak binding; equivalent hard particle model
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Ask authors/readers for more resources
The term macromolecular crowding denotes the combined effects of high volume fractions of nominally unrelated macromolecules upon the equilibrium and transport properties of all macrosolutes, dilute as well as concentrated, in the crowded medium. We present a formal partitioning of the total crowding effect into contributions from steric exclusion (excluded volume) and weak, nonspecific attractive interactions between a concentrated crowding agent and reactant and product species present at trace concentration. A numerical example of the combined effect of both steric and chemical interactions between crowder and tracer upon the reversible dimerization of tracer is presented, based upon reasonable estimates of the magnitude of both repulsive and attractive interactions between tracer and crowder species. (c) 2012Wiley Periodicals, Inc. Biopolymers 99: 239244, 2013.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available