Journal
BIOPOLYMERS
Volume 95, Issue 11, Pages 733-745Publisher
WILEY
DOI: 10.1002/bip.21646
Keywords
shear flow; protein; unfolding; aggregation; amyloid fibril; physiology; bioprocessing
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Protein molecules are subjected to potentially denaturing fluid shear forces during processing and in circulation in the body. These complex molecules, involved in numerous biological functions and reactions, can be significantly impaired by molecular damage. There have been many studies on the effects of hydrodynamic shear forces on protein structure and function. These studies are reviewed and the implications to bioprocessing and pathophysiology of certain diseases are discussed. (C) 2011 Wiley Periodicals, Inc. Biopolymers 95: 733-745, 2011.
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