Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 15, Pages 12155-12163Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b14566
Keywords
aggregation-induced emission luminogen; mesoporous silica nanoparticles; CuS; cell imaging drug release; chemo-photothermal therapy
Funding
- State Basic Research Project of China [2014CB931802]
- National Natural Science Foundation of China [21320102001, 21621001]
- 111 Project [B17020]
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A novel multifunctional drug delivery system has been constructed by assembling per-6-thio-beta-cydodextrin-modified ultrasmall CuS nanopartides (CD-CuS) onto fluorescent AIEgen-containing mesoporous silica nanoparticles (FMSN). The CD-CuS nanoparticles are anchored on the surface of benzimidazole-grafted FMSN, acting as a gatekeeper and photothermal agent. The prepared blue-emitting nanocomposite (FMSN@CuS) exhibits good biocompatibility and cell imaging capability. Anticancer drug doxorubicin hydrochloride (DOX) molecules are loaded into FMSN@CuS, and zero prerelease at physiological pH (7.4) and on-demand drug release at an acidic environment can be achieved due to the pH-responsive gate-opening of CD-CuS only at an acidic condition. The FMSN@CuS nanocomposite can generate obvious thermal effect after the exposure of 808 nm laser, which can also accelerate the DOX release. Meanwhile, the fluorescence intensity of DOX-loaded FMSN@CuS increases with the release of DOX, and the intracellular drug release process can be tracked according to the change of luminescence intensity. More importantly, DOX-loaded FMSN@CuS displays efficient anticancer effects in vitro upon 808 nm laser irradiation, demonstrating a good synergistic therapeutic effect via combining enhanced chemotherapy and photothermal therapy.
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